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In lung, microvascular development in backward fetal and aboriginal postnatal activity is characterized by endothelial corpuscle proliferation, capillary alignment in aing adjacency to the alveolar epithelium, and capillary adjustment (3, 4). The endothelial cell-specific mitogen VEGF is a above advocate of angiogenesis. Flk-1 is a tyrosine kinase receptor for VEGF that is bidding mainly on endothelial cells. Archetype of the VEGF gene can be induced by the archetype agency HLF. Glucocorticoids, which attune lung development and alveolarization, acerb arrest VEGF announcement by several corpuscle types in vitro but access VEGF mRNA in animal lung explants (27).

A above award of this abstraction is that VEGF and Flk-1 mRNA affluence increases in alongside during backward fetal and postnatal abrasion lung development. Developed lung retains almost aerial levels of VEGF mRNA, although little endothelial corpuscle admeasurement occurs at this time. The above beef cogent VEGF mRNA at all ages advised are in the alveolar epithelium, although mesenchymal beef in beginning lung had apparent message. We detected a baby but statistically cogent access in VEGF mRNA in the DEX animals, but dexamethasone did not decidedly adapt VEGF protein in vivo. Unlike stus in vitro, our agreement begin no inhibitory aftereffect of dexamethasone, alike in almost ample doses, on lung VEGF expression.

During the beginning date of animal lung development (0–8 wk), broadcast archaic claret argosy are formed from

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