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Sanofi and Regeneron Announce Complete Dupilumab Topline After-effects From Phase 3 Balloon in Amoral Assiduous Asthma

– Investigational dupilumab bargain astringent asthma attacks and bigger lung action – 

Paris, France and Tarrytown, New York – September 11, 2017 – Sanofi and Regeneron Pharmaceuticals, Inc. today appear that the cardinal Phase 3 LIBERTY ASTHMA QUEST abstraction of dupilumab in a ample citizenry of patients with uncontrolled, assiduous asthma met its two primary endpoints.

Dupilumab, back added to accepted therapies, bargain astringent asthma attacks (exacerbations) and bigger lung function. At 52 weeks, in the 300 mg dosage group, dupilumab bargain astringent asthma attacks by 46 percent in the all-embracing population, 60 percent in patients with 150 eosinophilic cells/microliter or greater, and 67 percent in patients with 300 eosinophilic cells/microliter or greater (p beneath than 0.001 for all groups). At 12 weeks, in the 300 mg dupilumab dosage group, beggarly advance in lung action over placebo as adjourned by affected expiratory aggregate over one added (FEV1) with dupilumab was 130 mL (9 percent) in the all-embracing population, 210 mL (11 percent) in patients with 150 eosinophilic cells/microliter or greater, and 240 mL (18 percent) in patients with 300 eosinophilic cells/microliter or greater (p beneath than 0.001 for all groups).

The companies plan to abide a Supplemental Biologics Authorization

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